Roberto De Zerbi, currently the new head coach of Tottenham, had his first home game in October 2022 while managing Brighton in the English Premier League against his current club, Tottenham.
Idman.Biz reports that Brighton lost that match with a score of 0:1.
Interestingly, the Italian specialist's first home game as Tottenham's head coach also coincides with his former team, Brighton.

This kind of coincidence is recorded for the first time in Premier League history.